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According to the research and studies, there is no conclusive evidence as to whether patients with testosterone deficiency (TD) who benefit from testosterone replacement therapy (TRT) must continue the treatment for the rest of their lives.

In some patients, the effect of TRT does not maintain after stopping TRT, and some patients show no significant testosterone deficiency (TD) symptoms after the therapy being stopped.

Always remember that testosterone replacement therapy should only be done with the supervision of a qualified professional in the field of testosterone replacement therapy.

It is essential to give you the best effect possible while minimizing or eliminating unwanted side effects.

There are different ways that TRT is done.

Professionals or the experienced in testosterone replacement therapy will let you choose which method is right for you and with which plan you are most comfortable.

Indefinitely, TRT does not fully cure low testosterone.

If you stop taking it, you may experience the return of some symptoms like- Irritability, Anxiety, fatigue, loss of appetite, insomnia, and a decrease of libido.

Benefits of Testosterone Replacement Therapy

When optimal Testosterone levels (800-1300) are combined with a proper diet & exercise program (weight/resistance training & cardio), you can expect the following benefits:

  • Increased Sexual Desire, sexual drive, and performance
  • Weight Loss
  • Improved Muscle Mass
  • Increased Energy Levels
  • Improved mental health
  • Decreased Irritability And Anxiety
  • Restore happiness

Testosterone Replacement Therapy Effect Timeline

Testosterone Replacement Therapy, Result, and Effect Time Frame.

(These are simply guidelines, and the exact time frame may vary between individuals.)

Increased Sexual Desire Effects on sexual desire appear after 3 weeks while respite at 6 weeks, with no further increments expected.
Erections/Ejaculations Improvements in erections/ejaculations may require up to 6 months.
Quality of life Effects on quality of life demonstrate within 3–4 weeks, but maximum benefits take longer.
Depressive mood Effects on depressive mood become noticeable after 3–6 weeks with a maximum of up to 18–30 weeks.
Prostate-Specific Antigen (PSA) Prostate-specific antigen and volume rise, marginally, respite at 12 months further, the increase should be related to aging rather than therapy.
Lipids Effects on lipids appear after 4 weeks, but it may take up to 6–12 months.
Insulin Sensitivity Effect on Insulin sensitivity may improve within a few days.
Glycemic Control Effects on glycemic control become noticeable only after 3–12 months.
Improved Fat Mass

Lean Body Mass 

Muscle Mass & Strength

Changes in fat mass, lean body mass, and muscle strength occur within 12–16 weeks, stabilize at 6–12 months, but can barely continue over the years.
Higher Energy Levels An increase in energy is noticeable within 2 months after starting therapy.
Erythropoiesis Erythropoiesis effects are evident at 3 months, peeking up to 9–12 months.
Inflammation The effects on inflammation can be seen within 3–12 weeks.
Bone Density Effects on bone are evident already after 6 months while continuing at least for 3 years.
Decreased Irritability and Anxiety Changes are usually seen within 6-8 weeks and should reach maximum effect by 9 weeks.


In men with hypogonadism who respond to TRT, a more extended treatment period can improve the durability of response after TRT cessation, regardless of the type of testosterone treatment.

Furthermore, regular exercise can lead to a 10-fold increase in the probability of a maintained response after TRT cessation.

Thus, the adoption of regular exercise during therapy could reduce the risks, costs, and burdens of TRT.